Research Overview 

Tremendous efforts will continue towards developing novel synthetic methodologies with improved efficiencies and are more environmentally benign. Simultaneously, the focus has preserved such steady and impressive goals and is also equally well aware of the rapidly changing nature of chemical synthesis and related domains. 

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Green chemistry is a new way of looking at photoredox catalysis and electrochemical synthesis, offering significant environmental and economic advantages over conventional synthetic methods. From the perspective of the rising need for green and sustainable synthetic methodologies, photocatalytic and electrochemical transformations presently the hottest research area in advanced chemical synthesis.

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Current Overview of our Research

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At Osmania University, our research group actively working on organosulfur chemistry, particularly, the applications of thiosulfonates and beta-iodovinyl sulfones were well demonstrated. Several research projects are in progress, few outcomes were already published, and other results are in various publications. 

 

To mention a few achievements:

(i) Thiosulfonates (RS–SO2R1) are the privileged class of organosulfur compounds and we demonstrated a versatile precursor, such as sulfenylation agent (Asian J. Org. Chem., 2019, 8, 2269-2275 and Eur. J. Org. Chem., 2019, 3771-3775), sulfonylation agent (Tetrahedron Lett., 2018, 59, 2014-2017) and thiosulfonylation agent (Adv. Synth. Catal., 2019, 361, 1587-1591; Org. Biomol. Chem. 2020, 18, 3243-3248). Moreover, the allyl thiosulfonates were readily-assembled using the Morita-Baylis-Hillman allyl bromides and sodium arylthiosulfonates without any reagent/catalyst (RSC Adv., 2018, 8, 40446–40453). The allyl thiosulfonates were successfully transformed into a set of two synthetically viable allyl disulfanes in the presence of Cs2CO3 is reported.

(ii) Unprecedented reactivity of ‘beta-iodovinyl sulfones’ was explored in our laboratory. An operationally simple metal-free sulfenylation of beta-iodovinyl sulfones with thiosulfonates in the presence of NaOAc in DMF to provide a wide range of beta-keto thiosulfones in moderate to high yields have been developed (Eur. J. Org. Chem., 2019, 3771-3775); The palladium-catalyzed annulation between beta-iodovinyl sulfones and 2-halophenols annulation process involving oxa-Michael addition-elimination and intramolecular Heck reaction leading to form 2,3-disubstituted benzofurans (aryl benzofuryl sulfones) in good to high yields (Adv. Synth. Catal., 2020, 362, 1317-1322). Many more projects are being in progress on ‘beta-iodovinyl sulfones’ and will be published in due course.

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